Coleman R, Trembath R C, Harper J I
Department of Dermatology, Hospitals for Sick Children, London, UK.
Lancet. 1993 May 1;341(8853):1121-2. doi: 10.1016/0140-6736(93)93130-s.
Genetic linkage has been reported between atopic respiratory disease and chromosome site 11q13. We recruited 95 multiplex families through probands with active atopic eczema. Linkage analyses between atopy and markers on 11q13 excluded a major susceptibility locus for atopy in this region. Nor was there significant deviation from the expected proportions of alleles shared by affected sib-pairs. When we analysed families according to parental atopic phenotype, we observed a positive lod score (0.8) in 19 families with unaffected fathers, in contrast to markedly negative scores for other combinations of affected parental phenotype. The possibility of a maternal influence on the inheritance of atopy cannot, therefore, be excluded.
已有报道称特应性呼吸道疾病与染色体11q13位点之间存在基因连锁。我们通过患有活动性特应性皮炎的先证者招募了95个多位点家庭。对11q13上的特应性与标记物之间进行连锁分析，排除了该区域存在特应性主要易感基因座的可能性。受影响同胞对共享的等位基因比例也未出现显著偏离预期比例的情况。当我们根据父母的特应性表型对家庭进行分析时，我们在19个父亲未患病的家庭中观察到一个正的对数优势分数（0.8），相比之下，其他受影响父母表型组合的分数则明显为负。因此，不能排除母体对特应性遗传的影响。
