氟司喹南对麻醉大鼠缺血性心律失常及心室环核苷酸含量的影响。
Effect of flosequinan on ischaemia-induced arrhythmias and on ventricular cyclic nucleotide content in the anaesthetized rat.
作者信息
Jones R B, Frodsham G, Dickinson K, Foster G A
机构信息
Boots Pharmaceuticals, Research Department, Nottingham.
出版信息
Br J Pharmacol. 1993 Apr;108(4):1111-6. doi: 10.1111/j.1476-5381.1993.tb13513.x.
Abstract
- Flosequinan, milrinone, isoprenaline and forskolin given intravenously at similarly hypotensive doses have been evaluated in separate studies for their effect on ischaemia-induced arrhythmias and on ventricular cyclic nucleotide content following coronary artery ligation in the pentobarbitone anaesthetized rat. 2. Flosequinan did not affect mortality or arrhythmias following coronary artery ligation in either study and no change in ventricular cyclic nucleotide content was observed. 3. Isoprenaline caused a significant increase in mortality (P < 0.05) in both studies whereas milrinone and forskolin caused a significant increase in mortality in only one of the two studies conducted. All three agents caused significant increases in cyclic AMP which were associated with increased incidence of arrhythmias. 4. When compared at similarly hypotensive doses, flosequinan, in contrast to milrinone, isoprenaline and forskolin, did not influence ischaemia-induced arrhythmias or raise ventricular cyclic nucleotide levels in the anesthetized rat.
摘要
- 在戊巴比妥麻醉的大鼠中，分别研究了静脉注射剂量相似的氟司喹南、米力农、异丙肾上腺素和福斯高林对缺血诱导的心律失常以及冠状动脉结扎后心室环核苷酸含量的影响。2. 在两项研究中，氟司喹南都未影响冠状动脉结扎后的死亡率或心律失常，且未观察到心室环核苷酸含量的变化。3. 在两项研究中，异丙肾上腺素均导致死亡率显著增加（P < 0.05），而米力农和福斯高林仅在两项研究中的一项中导致死亡率显著增加。这三种药物均导致环磷酸腺苷显著增加，且与心律失常发生率增加相关。4. 在相似的低血压剂量下进行比较时，与米力农、异丙肾上腺素和福斯高林不同，氟司喹南不影响麻醉大鼠缺血诱导的心律失常，也不提高心室环核苷酸水平。
相似文献
1
Effect of flosequinan on ischaemia-induced arrhythmias and on ventricular cyclic nucleotide content in the anaesthetized rat.氟司喹南对麻醉大鼠缺血性心律失常及心室环核苷酸含量的影响。
Br J Pharmacol. 1993 Apr;108(4):1111-6. doi: 10.1111/j.1476-5381.1993.tb13513.x.
2
Effects of rolipram, pimobendan and zaprinast on ischaemia-induced dysrhythmias and on ventricular cyclic nucleotide content in the anaesthetized rat.咯利普兰、匹莫苯丹和扎普司特对麻醉大鼠缺血性心律失常及心室环核苷酸含量的影响。
Eur J Anaesthesiol. 2003 Mar;20(3):205-11. doi: 10.1017/s0265021503000358.
3
Failure of nitric oxide donors to alter arrhythmias induced by acute myocardial ischaemia or reperfusion in anaesthetized rats.一氧化氮供体未能改变麻醉大鼠急性心肌缺血或再灌注所诱发的心律失常。
Br J Pharmacol. 1995 Jan;114(2):349-56. doi: 10.1111/j.1476-5381.1995.tb13233.x.
4
5
Effects of cyclic GMP elevation on isoprenaline-induced increase in cyclic AMP and relaxation in rat aortic smooth muscle: role of phosphodiesterase 3.环磷酸鸟苷升高对异丙肾上腺素诱导的大鼠主动脉平滑肌中环磷酸腺苷增加及舒张的影响：磷酸二酯酶3的作用
Br J Pharmacol. 1996 Oct;119(3):471-8. doi: 10.1111/j.1476-5381.1996.tb15696.x.
6
Combined phosphodiesterase inhibition and beta-blockade in the GI104313, decreases ischemia-induced arrhythmias in the rat.在大鼠中，GI104313联合磷酸二酯酶抑制和β受体阻滞剂可减少缺血诱导的心律失常。
Can J Anaesth. 2001 May;48(5):486-92. doi: 10.1007/BF03028315.
7
Differential inotropic effects of flosequinan in ventricular muscle from normal ferrets versus patients with end-stage heart failure.氟司喹南对正常雪貂与终末期心力衰竭患者心室肌的变力作用差异。
Br J Pharmacol. 1992 Jul;106(3):511-6. doi: 10.1111/j.1476-5381.1992.tb14367.x.
8
Effects of cyclic AMP-affecting agents on contractile reactivity of isolated mesenteric and renal resistance arteries of the rat.环磷酸腺苷作用剂对大鼠离体肠系膜和肾阻力动脉收缩反应性的影响。
Br J Pharmacol. 1990 Dec;101(4):859-64. doi: 10.1111/j.1476-5381.1990.tb14171.x.
9
Synergistic action of cyclic GMP on catecholamine-induced chloride current in guinea-pig ventricular cells.环磷酸鸟苷对豚鼠心室肌细胞儿茶酚胺诱导的氯离子电流的协同作用。
J Physiol. 1992;453:647-61. doi: 10.1113/jphysiol.1992.sp019249.
10
Comparison of the effects of isobutylmethylxanthine and milrinone on ischaemia-induced arrhythmias and platelet aggregation in anaesthetized rabbits.异丁基甲基黄嘌呤和米力农对麻醉兔缺血诱导的心律失常及血小板聚集影响的比较
Br J Pharmacol. 1989 Sep;98(1):318-24. doi: 10.1111/j.1476-5381.1989.tb16897.x.
引用本文的文献
1
Failure of nitric oxide donors to alter arrhythmias induced by acute myocardial ischaemia or reperfusion in anaesthetized rats.一氧化氮供体未能改变麻醉大鼠急性心肌缺血或再灌注所诱发的心律失常。
Br J Pharmacol. 1995 Jan;114(2):349-56. doi: 10.1111/j.1476-5381.1995.tb13233.x.
本文引用的文献
1
Simple techniques for the surgical occlusion of coronary vessels in the rat.大鼠冠状动脉血管手术闭塞的简单技术。
Angiology. 1960 Oct;11:398-407. doi: 10.1177/000331976001100505.
2
Coronary artery ligation in anesthetized rats as a method for the production of experimental dysrhythmias and for the determination of infarct size.在麻醉大鼠中进行冠状动脉结扎，作为产生实验性心律失常和测定梗死面积的一种方法。
J Pharmacol Methods. 1980 Jun;3(4):357-68. doi: 10.1016/0160-5402(80)90077-7.
3
Development of a severe model of early coronary artery ligation-induced dysrhythmias in the anaesthetized rat.麻醉大鼠早期冠状动脉结扎诱发心律失常严重模型的建立。
Br J Pharmacol. 1981 Aug;73(4):951-9. doi: 10.1111/j.1476-5381.1981.tb08750.x.
4
Modulation of myocardial cyclic AMP and vulnerability to fibrillation in the rat heart.大鼠心脏中心肌环磷酸腺苷的调节与对颤动的易感性
Fed Proc. 1983 May 15;42(8):2460-4.
5
Cyclic AMP mediated arrhythmias induced in the ischaemic pig heart.环磷酸腺苷介导的缺血猪心脏心律失常
Basic Res Cardiol. 1981 Jul-Aug;76(4):443-8. doi: 10.1007/BF01908339.
6
The genesis of arrhythmias during myocardial ischemia. Dissociation between changes in cyclic adenosine monophosphate and electrical instability in the rat.心肌缺血期间心律失常的发生机制。大鼠中环磷酸腺苷变化与电不稳定之间的分离。
Circ Res. 1985 Nov;57(5):668-75. doi: 10.1161/01.res.57.5.668.
7
The role of catecholamines in the production of ischaemia-induced ventricular arrhythmias in the rat in vivo and in vitro.儿茶酚胺在大鼠体内及体外缺血诱导的室性心律失常产生中的作用。
Br J Pharmacol. 1986 Jan;87(1):265-77. doi: 10.1111/j.1476-5381.1986.tb10180.x.
8
Effect of phosphodiesterase inhibitors on survival of patients with chronic congestive heart failure.磷酸二酯酶抑制剂对慢性充血性心力衰竭患者生存率的影响。
Am J Cardiol. 1989 Jan 3;63(2):41A-45A. doi: 10.1016/0002-9149(89)90392-5.
9
10
Pharmacology of flosequinan.氟司喹南的药理学
Am Heart J. 1991 Mar;121(3 Pt 1):974-83. doi: 10.1016/0002-8703(91)90229-b.
Zotero 插件