Lin P J, Pearson P J, Chang C H
Dept. of Thoracic & Cardiovascular Surgery, Chang Gung Memorial Hospital, Taipei, Taiwan, R.O.C.
Changgeng Yi Xue Za Zhi. 1993 Mar;16(1):1-13.
The endothelium modulates vascular tone by liberating both dilator [endothelium-derived relaxing factors; EDRFs]and constrictor substances [endothelium-derived contracting factors; EDCFs]. This review focused on endothelium-derived relaxing factor, its discovery, characteristics, synthesis and interaction with vascular smooth muscle. The major endothelium-derived relaxing factor is nitric oxide formed from L-arginine, which activates guanylate cyclase in the smooth muscle, leading to accumulation of cyclic-GMP. Endothelial cells can also release endothelium-derived hyperpolarizing factor EDHF which also cause endothelium-dependent relaxation.
内皮细胞通过释放舒张因子（内皮源性舒张因子；EDRFs）和收缩物质（内皮源性收缩因子；EDCFs）来调节血管张力。本综述聚焦于内皮源性舒张因子，包括其发现、特性、合成以及与血管平滑肌的相互作用。主要的内皮源性舒张因子是由L-精氨酸生成的一氧化氮，它可激活平滑肌中的鸟苷酸环化酶，导致环磷酸鸟苷的积累。内皮细胞还可释放内皮源性超极化因子（EDHF），其也可引起内皮依赖性舒张。
