Hogan D, Berman N E
Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City 66160-7400.
Brain Res Dev Brain Res. 1993 Feb 19;71(2):221-38. doi: 10.1016/0165-3806(93)90174-9.
The development of somatostatin immunoreactive (SOM-ir) neurons in cat striate and extrastriate cortex was studied to determine whether temporal changes in the morphology, distribution and density of SOM-ir neurons during development would provide clues to the emergence of specific cortical areas. The visual cortical areas examined included areas 17-19 and 7, posteromedial lateral suprasylvian, posterolateral lateral suprasylvian cortex and splenial visual area. We observed that the pattern of SOM-ir neurons in the cortical plate reflects the maturation of the cortical plate. At 1 week of age, SOM-ir neurons were only found in layers V and VI of the developing cortex; by 2 weeks of age, SOM-ir neurons were found in layer IV; and by 3 weeks of age, SOM-ir neurons were located in all layers of the cortex except layer I. SOM-ir neurons in the subplate were much more numerous under lateral cortical areas than under medial areas. This difference decreased over the first 2 postnatal weeks and by the 14th day after birth (P14), the distribution and numbers of SOM-ir neurons in the subplate/white matter had reached the adult pattern. The timing of exuberant SOM expression in the subplate suggests a function in the formation of visual corticocortical connections which begin to develop during the first postnatal week in the kitten.
研究了猫纹状皮层和纹外皮层中生长抑素免疫反应性（SOM-ir）神经元的发育情况，以确定发育过程中SOM-ir神经元的形态、分布和密度的时间变化是否能为特定皮层区域的出现提供线索。所检查的视觉皮层区域包括17-19区和7区、后内侧外侧上薛氏回、后外侧外侧上薛氏回皮层和压部视觉区。我们观察到，皮层板中SOM-ir神经元的模式反映了皮层板的成熟。在1周龄时，仅在发育中皮层的V层和VI层发现SOM-ir神经元；到2周龄时，在IV层发现SOM-ir神经元；到3周龄时，SOM-ir神经元位于除I层外的皮层各层。皮层下板中的SOM-ir神经元在外侧皮层区域比在内侧区域多得多。这种差异在出生后的前2周内减小，到出生后第14天（P14），皮层下板/白质中SOM-ir神经元的分布和数量已达到成年模式。皮层下板中SOM表达旺盛的时间表明其在视觉皮质-皮质连接形成中起作用，这种连接在小猫出生后的第一周开始发育。
