Pancholi P, Mirza A, Bhardwaj N, Steinman R M
Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021.
Science. 1993 May 14;260(5110):984-6. doi: 10.1126/science.8098550.
CD4+ helper T cells mediate resistance to tuberculosis, presumably by enhancing the antimicrobial activity of macrophages within which the Mycobacterium tuberculosis organism grows. A first step in resistance should be the presentation of mycobacterial antigens by macrophages to CD4+ T cells. However, when the antigenic stimulus is limited to organisms growing in human monocytes, the organisms become sequestered from immune CD4+ T cells. This block in presentation is selective for growing mycobacteria and not for other stimuli. Sequestration would allow replicating organisms to persist in infected individuals and may contribute to virulence.
CD4 +辅助性T细胞介导对结核病的抵抗力，大概是通过增强结核分枝杆菌生长的巨噬细胞的抗菌活性来实现的。抵抗力的第一步应该是巨噬细胞将分枝杆菌抗原呈递给CD4 + T细胞。然而，当抗原刺激仅限于在人类单核细胞中生长的生物体时，这些生物体就会与免疫CD4 + T细胞隔离。这种呈递障碍对生长中的分枝杆菌具有选择性，而对其他刺激则没有。隔离会使正在复制的生物体在受感染个体中持续存在，并可能导致毒力增强。
