Nisikori K, Nagoshi K, Shimizu K, Yoshida N
Department of Obstetrics and Gynecology, Okayama University Medical School, Japan.
Int J Gynaecol Obstet. 1993 May;41(2):147-52. doi: 10.1016/0020-7292(93)90697-u.
Fetal growth in early pregnancy was estimated by transvaginal ultrasonic measurement and serum hCG measurement in 13 women who became pregnant through in vitro fertilization and embryo transfer treatment. The first day of observation of a gestational sac (GS) or fetal heart movement (FHM) of over 120 beats/min confirmed the pregnancy. There were 6 or 7 days difference in GS or FHM confirmation within 20 or 30 days after insemination, although statistical deviations were very small (GS: 21.3 +/- 1.8, FHM: 29.5 +/- 1.8 days after insemination, mean +/- S.D.). Increases in crown-rump length (CRL) and serum hCG were used as indicators of fetal growth. There was a good correlation between CRL or serum hCG and days after insemination (CRL: r = 0.95, n = 55; hCG: r = 0.96, n = 77), and individual cases had almost the same velocity of CRL growth and serum hCG elevation as each regression line. This data suggests that each embryo has a different growth velocity from the fertilized oocyte until the first clinical confirmation of pregnancy.
通过经阴道超声测量和血清人绒毛膜促性腺激素（hCG）测量，对13名通过体外受精和胚胎移植治疗成功怀孕的女性孕早期的胎儿生长情况进行了评估。观察到妊娠囊（GS）或胎儿心率超过120次/分钟的胎儿心脏活动（FHM）的第一天被确认为妊娠。在授精后20或30天内，GS或FHM确认时间存在6或7天的差异，尽管统计偏差非常小（GS：授精后21.3±1.8天，FHM：授精后29.5±1.8天，平均值±标准差）。顶臀长度（CRL）的增加和血清hCG被用作胎儿生长的指标。CRL或血清hCG与授精后天数之间存在良好的相关性（CRL：r = 0.95，n = 55；hCG：r = 0.96，n = 77），并且个别病例的CRL生长速度和血清hCG升高速度与每条回归线几乎相同。该数据表明，从受精卵到首次临床确认妊娠，每个胚胎都有不同的生长速度。
