Gaitan D, Loosen P T, Orth D N
Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
J Clin Endocrinol Metab. 1993 Jun;76(6):1580-2. doi: 10.1210/jcem.76.6.8099078.
Cushing's disease (pituitary ACTH-dependent Cushing's syndrome) has been described in association with the syndrome of multiple endocrine neoplasia type I (MEN-I). Cushing's disease is uncommon in MEN-I and has not been reported in more than one member of a kindred. Here we describe a mother and her daughter with Cushing's disease and major depressive disorder. The mother, her other daughter, and two other relatives also had primary hyperparathyroidism. We believe this to be the first reported instance of hereditary Cushing's disease as a manifestation of MEN-I.
库欣病（垂体促肾上腺皮质激素依赖性库欣综合征）已被描述与I型多发性内分泌腺瘤病（MEN-I）相关。库欣病在MEN-I中并不常见，且尚未在一个家族的一名以上成员中报道过。在此，我们描述了一位患有库欣病和重度抑郁症的母亲及其女儿。这位母亲、她的另一个女儿以及另外两名亲属也患有原发性甲状旁腺功能亢进症。我们认为这是首次报道遗传性库欣病作为MEN-I的一种表现形式。
