Haddad Q, Sobayo E I, Basit O B, Rotimi V O
Division of Infectious Diseases, Security Forces Hospital, Riyadh, Kingdom of Saudi Arabia.
J Hosp Infect. 1993 Mar;23(3):211-22. doi: 10.1016/0195-6701(93)90026-v.
An outbreak of methicillin-resistant Staphylococcus aureus (MRSA) occurred in a neonatal intensive care unit (NICU) over a period of 2 months involving 16 babies, mainly of low birth weight. Arbitrary grouping of the isolates showed that there were apparently three different strains involved in the outbreak, as determined only by antibiogram. Twenty-three out of 27 isolates were allocated to 'group 1' based on antibiotic sensitivity pattern. Control of spread of the MRSA in the unit was difficult because of some technical constraints but eradication was finally achieved by cohort nursing and treatment with topical mupirocin in paraffin base. All MRSA isolates were resistant to gentamicin, erythromycin, tetracycline and at least four other antibiotics but sensitive to vancomycin. Overcrowding, limited space, inadequate cleaning of the equipment and initial lack of correct attitude to scrupulous handwashing techniques, all appeared to contribute to the ease of spread of the strains involved.
在两个月的时间里，一家新生儿重症监护病房（NICU）爆发了耐甲氧西林金黄色葡萄球菌（MRSA）感染，涉及16名婴儿，主要是低体重儿。对分离菌株进行任意分组显示，仅根据抗菌谱确定，此次爆发显然涉及三种不同菌株。27株分离菌株中有23株根据抗生素敏感性模式被归入“第1组”。由于一些技术限制，控制该病房MRSA的传播很困难，但最终通过分组护理和使用石蜡基莫匹罗星局部治疗实现了根除。所有MRSA分离菌株对庆大霉素、红霉素、四环素和至少其他四种抗生素耐药，但对万古霉素敏感。过度拥挤、空间有限、设备清洁不足以及最初对手部严格清洗技术缺乏正确态度，似乎都有助于相关菌株的传播。
