Bauché F, Sabourault D, Giudicelli Y, Nordmann J, Nordmann R
Arch Int Physiol Biochim. 1978 May;86(2):363-75. doi: 10.3109/13813457809069911.
The effects of the administration of different fatty liver inducing drugs on the serum lipoprotein lipase activating ability was investigated in rats. Addition of serum from 2-mercaptoethanol-, 2-mercaptoacetate-, ethionine- or D-galactosamine- treated rats failed to activate heart and adipose tissue lipoprotein lipase from control rats. The activating effect of serum was only slightly reduced in isopropanol-treated rats, whereas it was found unaffected in ethanol-treated ones. Electrophoresis of the lipoproteins and of the very low density lipoproteins (VLDL) fraction of sera from 2-mercaptoethanol-, 2-mercaptoacetate-, isopropanol-, ethionine- and D-galactosamine-treated rats suggest that the lack of lipoprotein lipase activation ability of these sera is most probably related to the impairing effects of these drugs upon VLDL metabolism, i.e. reduction of VLDL secretion in the case of 2-mercaptoethanol, 2-mercaptoacetate and isopropanol, production of abnormal VLDL in the case of D-galactosamine and both decreased VLDL secretion and production of abnormal VLDL in the case of ethionine.
研究了给大鼠施用不同的脂肪肝诱导药物对血清脂蛋白脂肪酶激活能力的影响。添加来自经2-巯基乙醇、2-巯基乙酸、乙硫氨酸或D-半乳糖胺处理的大鼠的血清，未能激活对照大鼠心脏和脂肪组织的脂蛋白脂肪酶。在经异丙醇处理的大鼠中，血清的激活作用仅略有降低，而在经乙醇处理的大鼠中，发现其未受影响。对来自经2-巯基乙醇、2-巯基乙酸、异丙醇、乙硫氨酸和D-半乳糖胺处理的大鼠血清中的脂蛋白和极低密度脂蛋白（VLDL）部分进行电泳分析表明，这些血清缺乏脂蛋白脂肪酶激活能力很可能与这些药物对VLDL代谢的损害作用有关，即2-巯基乙醇、2-巯基乙酸和异丙醇会减少VLDL分泌，D-半乳糖胺会产生异常VLDL，而乙硫氨酸则会同时减少VLDL分泌并产生异常VLDL。
