Riekkinen P, Sirviö J, Toivanen L, Riekkinen M, Lammintausta R, Riekkinen P
University of Kuopio, Department of Neurology, Finland.
Eur J Pharmacol. 1993 Apr 28;235(2-3):317-20. doi: 10.1016/0014-2999(93)90154-a.
The present experiments were undertaken to study whether blockade of alpha 1-adrenoceptors would prevent the high-voltage spindle suppressing effect of atipamezole, an alpha 2-adrenoceptor antagonist. In adult rats, an alpha 1-adrenoceptor antagonist, prazosin, increased dose dependently the high voltage spindles in saline and atipamezole-pretreated rats. In addition, in aged rats prazosin blocked the high-voltage spindle suppressing action of atipamezole. Prazosin produced a smaller increase in high-voltage spindle values in aged than in adult rats. According to the present results, alpha 2-adrenoceptor antagonists may suppress high-voltage spindles indirectly by activating alpha 1-adrenoceptors in young and aged rats.
本实验旨在研究α1肾上腺素能受体阻断是否会阻止α2肾上腺素能受体拮抗剂阿替美唑的高压纺锤波抑制作用。在成年大鼠中，α1肾上腺素能受体拮抗剂哌唑嗪剂量依赖性地增加了生理盐水处理和阿替美唑预处理大鼠的高压纺锤波。此外，在老年大鼠中，哌唑嗪阻断了阿替美唑的高压纺锤波抑制作用。哌唑嗪在老年大鼠中引起的高压纺锤波值增加幅度小于成年大鼠。根据目前的结果，α2肾上腺素能受体拮抗剂可能通过激活年轻和老年大鼠的α1肾上腺素能受体间接抑制高压纺锤波。
