小鼠Hox3基因簇基因的组织与表达
Organization and expression of mouse Hox3 cluster genes.
作者信息
Goto J, Miyabayashi T, Wakamatsu Y, Takahashi N, Muramatsu M
机构信息
Department of Biochemistry, School of Medicine, University of Tokyo, Japan.
出版信息
Mol Gen Genet. 1993 May;239(1-2):41-8. doi: 10.1007/BF00281599.
We determined the physical linkage of six mouse Hox3 homeobox sequences, including a new homeobox sequence (Hox3.5), by analysis of overlapping genomic clones. Additionally, we defined the locations of Hox1.7 and Hox1.8 in the Hox1 cluster. Analysis of the expression patterns of Hox3.6 and Hox3.5 during embryogenesis revealed that the relationship between relative position in the Hox3 cluster and expression domain along antero-posterior axis appears similar to that seen for members of the other Hox clusters.
我们通过分析重叠的基因组克隆，确定了六个小鼠Hox3同源框序列的物理连锁关系，其中包括一个新的同源框序列（Hox3.5）。此外，我们确定了Hox1.7和Hox1.8在Hox1基因簇中的位置。对Hox3.6和Hox3.5在胚胎发育过程中表达模式的分析表明，Hox3基因簇中的相对位置与沿前后轴的表达域之间的关系，似乎与其他Hox基因簇成员的情况相似。
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