Castaigne S
Service d'Hématologie Adulte, Hôpital Saint-Louis, Paris, France.
Nouv Rev Fr Hematol (1978). 1993 Feb;35(1):13-4.
Hereditary adenosine deaminase deficiency results in failure of the lymphocyte development. This occurs because of the accumulation of deoxyadenosine nucleotides. 2-chlorodeoxyadenosine (2CdA) resists the action of adenosine deaminase and accumulates in cells. In doses of 0.1 mg/kg/day given for seven days, 2CdA manifests low toxicity and has been found to be effective in patients with hairy cell leukemia, chronic lymphocytic leukemia, low grade lymphoma and acute myeloid leukemia. 2CdA appears like a very promising drug in these indications.
遗传性腺苷脱氨酶缺乏导致淋巴细胞发育失败。这是由于脱氧腺苷核苷酸的积累所致。2-氯脱氧腺苷（2CdA）可抵抗腺苷脱氨酶的作用并在细胞中蓄积。以0.1mg/kg/天的剂量给药7天，2CdA表现出低毒性，并且已发现其对毛细胞白血病、慢性淋巴细胞白血病、低度淋巴瘤和急性髓细胞白血病患者有效。在这些适应症中，2CdA似乎是一种非常有前景的药物。
