文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Gupta G S, Bajpai R, Kaw J L, Dutta K K, Ray P K

Industrial Toxicology Research Centre, Lucknow, India.

Hum Exp Toxicol. 1993 May;12(3):253-7. doi: 10.1177/096032719301200309.

Studies were carried out to explore the acute pulmonary effects of equal, split-dose, multiple inhalation exposures of rats to methyl isocyanate (MIC), (0.32 mg l-1, 8 min x 10 exposures) as reflected by alterations in bronchoalveolar lavage fluid (BALF) constituents and to evaluate recovery, if any, following survival in a MIC-free environment, 10 d after the last MIC exposure. 2. In the BALF of MIC-exposed rats, there was an increase in the total number of cells and the number of cells showing enhanced dye uptake and reduction of nitroblue tetrazolium chloride. The cell-free BALF showed increases in total protein, sialic acids and lactic acid contents and lactate dehydrogenase activity. 3. In rats exposed to MIC and sacrificed 10 d after survival in a MIC-free environment, there was a reduction in the cellular and biochemical constituents of BALF. The phagocytic potential of macrophages was, however, also decreased under this regime.

开展了多项研究，以探究大鼠等量、分剂量、多次吸入接触异氰酸甲酯（MIC，0.32毫克/升，8分钟×10次接触）后的急性肺部效应，这可通过支气管肺泡灌洗（BALF）成分的变化反映出来，并评估在末次接触MIC后10天，于无MIC环境中存活后的恢复情况（如有）。2. 在接触MIC的大鼠的BALF中，细胞总数以及显示染料摄取增强和氯化硝基四氮唑蓝还原的细胞数量均增加。无细胞BALF显示总蛋白、唾液酸和乳酸含量以及乳酸脱氢酶活性增加。3. 在接触MIC并于无MIC环境中存活10天后处死的大鼠中，BALF的细胞和生化成分减少。然而，在此条件下巨噬细胞的吞噬潜力也降低了。

Gupta G S, Bajpai R, Kaw J L, Dutta K K, Ray P K

Industrial Toxicology Research Centre, Lucknow, India.

Hum Exp Toxicol. 1993 May;12(3):253-7. doi: 10.1177/096032719301200309.

Studies were carried out to explore the acute pulmonary effects of equal, split-dose, multiple inhalation exposures of rats to methyl isocyanate (MIC), (0.32 mg l-1, 8 min x 10 exposures) as reflected by alterations in bronchoalveolar lavage fluid (BALF) constituents and to evaluate recovery, if any, following survival in a MIC-free environment, 10 d after the last MIC exposure. 2. In the BALF of MIC-exposed rats, there was an increase in the total number of cells and the number of cells showing enhanced dye uptake and reduction of nitroblue tetrazolium chloride. The cell-free BALF showed increases in total protein, sialic acids and lactic acid contents and lactate dehydrogenase activity. 3. In rats exposed to MIC and sacrificed 10 d after survival in a MIC-free environment, there was a reduction in the cellular and biochemical constituents of BALF. The phagocytic potential of macrophages was, however, also decreased under this regime.

开展了多项研究，以探究大鼠等量、分剂量、多次吸入接触异氰酸甲酯（MIC，0.32毫克/升，8分钟×10次接触）后的急性肺部效应，这可通过支气管肺泡灌洗（BALF）成分的变化反映出来，并评估在末次接触MIC后10天，于无MIC环境中存活后的恢复情况（如有）。2. 在接触MIC的大鼠的BALF中，细胞总数以及显示染料摄取增强和氯化硝基四氮唑蓝还原的细胞数量均增加。无细胞BALF显示总蛋白、唾液酸和乳酸含量以及乳酸脱氢酶活性增加。3. 在接触MIC并于无MIC环境中存活10天后处死的大鼠中，BALF的细胞和生化成分减少。然而，在此条件下巨噬细胞的吞噬潜力也降低了。