Husch B, Eibl M M, Mannhalter J W
Department of Immunological Research, Immuno AG, Vienna, Austria.
AIDS Res Hum Retroviruses. 1993 May;9(5):405-13. doi: 10.1089/aid.1993.9.405.
The CD8-positive (CD8+) lymphocyte population in the chimpanzee is composed of two major subsets, a CD3-positive, CD8-positive (CD3+CD8+) and a CD3-negative, CD8-positive (CD3-CD8+) population. The aim of this study was to delineate the function of CD3+CD8+ T cells with respect to inhibition of HIV-1 replication. It could be shown that this cell population had the capacity to control the growth of HIV-1 in exogenously infected CD4-positive (CD4+) lymphocytes. This effect was observed only with cells from HIV-1-infected chimpanzees, was operative only in an autologous and not in a homologous situation, and was not due to cytotoxicity. CD3+CD8+ lymphocyte-mediated inhibition of HIV-1 replication was group-specific in that CD3+CD8+ cells of HIV-1 (IIIB)-infected chimpanzees were capable of inhibiting replication of HIV-1 strains IIIB, MN, and RF. The effect observed was operational during the early stages of HIV-1 replication only; the effector cells had to be added to CD4+ cells within 3 days after HIV-1 infection in order to suppress growth of the virus. The presence of CD3+CD8+ lymphocytes with anti-HIV-1 activity in the circulation of HIV-1-infected chimpanzees might contribute to the lack of progression toward AIDS observed in this species.
黑猩猩体内的CD8阳性（CD8+）淋巴细胞群体由两个主要亚群组成，一个是CD3阳性、CD8阳性（CD3+CD8+）群体，另一个是CD3阴性、CD8阳性（CD3-CD8+）群体。本研究的目的是阐明CD3+CD8+ T细胞在抑制HIV-1复制方面的功能。结果表明，该细胞群体能够在外源性感染的CD4阳性（CD4+）淋巴细胞中控制HIV-1的生长。这种效应仅在来自HIV-1感染黑猩猩的细胞中观察到，仅在自体而非同源情况下起作用，且并非由于细胞毒性。CD3+CD8+淋巴细胞介导的HIV-1复制抑制具有组特异性，即HIV-1（IIIB）感染黑猩猩的CD3+CD8+细胞能够抑制HIV-1毒株IIIB、MN和RF的复制。观察到的效应仅在HIV-1复制的早期阶段起作用；效应细胞必须在HIV-1感染后3天内添加到CD4+细胞中，以抑制病毒生长。在HIV-1感染的黑猩猩循环系统中存在具有抗HIV-1活性的CD3+CD8+淋巴细胞，这可能是该物种未出现向艾滋病进展的原因之一。
