Opjordsmoen S, Retterstöl N
University of Oslo, Gaustad Hospital, Norway.
Psychopathology. 1993;26(2):90-4. doi: 10.1159/000284805.
The effect of neuroleptics in the treatment of schizophrenia is well established. Some reports indicate that at least pimozide may be effective in delusional disorder as well. In this article a long-term follow-up study of 72 first-admitted patients with delusional disorder is described. Outcome in patients admitted during 1946-1948 was compared with that of patients admitted during 1958-1961. We did not find a more favourable outcome in the group admitted after the introduction of neuroleptics. This contradicts our earlier finding for patients with schizophrenic psychoses, indicating that neuroleptics generally may be more effective for schizophrenics than for patients with delusional disorder. Controlled drug trials in delusional disorder are strongly needed.
抗精神病药物在治疗精神分裂症方面的疗效已得到充分证实。一些报告表明，至少匹莫齐特在妄想症治疗中可能也有效。本文描述了对72例首次入院的妄想症患者的长期随访研究。将1946 - 1948年入院患者的治疗结果与1958 - 1961年入院患者的结果进行了比较。我们没有发现在引入抗精神病药物后入院的患者组有更有利的治疗结果。这与我们早期对精神分裂症患者的研究结果相矛盾，表明抗精神病药物通常对精神分裂症患者可能比对妄想症患者更有效。迫切需要对妄想症进行对照药物试验。
