Richardson B C, Buckmaster T, Keren D F, Johnson K J
Department of Medicine, University of Michigan, Ann Arbor.
Eur J Immunol. 1993 Jul;23(7):1450-5. doi: 10.1002/eji.1830230708.
The bone marrow produces large numbers of monocytes daily, but the mechanisms balancing production and elimination are unknown. In this report we demonstrate that macrophages (M phi) undergo apoptosis after activating autologous CD4+ cells. Since apoptosis is a genetically programmed response, these results argue that M phi death can be part of a normal immune response. This event may have relevance to monocyte/M phi homeostasis, as well as immune response regulation and host defenses to intracellular organisms.
骨髓每天产生大量单核细胞，但平衡其产生与清除的机制尚不清楚。在本报告中，我们证明巨噬细胞（M phi）在激活自体CD4 +细胞后会发生凋亡。由于凋亡是一种基因编程反应，这些结果表明M phi死亡可能是正常免疫反应的一部分。这一事件可能与单核细胞/M phi的体内平衡、免疫反应调节以及宿主对细胞内病原体的防御有关。
