Rajagopalan S, Wan D F, Habib G M, Sepulveda A R, McLeod M R, Lebovitz R M, Lieberman M W
Department of Pathology, Baylor College of Medicine, Houston, TX 77030.
Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6179-83. doi: 10.1073/pnas.90.13.6179.
The 5' region of the mouse gamma-glutamyltransferase (gamma GT; EC 2.3.2.2) gene has been cloned and analyzed. This analysis, combined with sequence information obtained from gamma GT cDNA clones, indicates that in mouse a single gamma GT gene codes for six different mRNAs that differ in their 5' sequences. Analysis of steady-state levels of gamma GT RNA reveals different expression patterns for these RNAs in different organs. The six different 5' sequences are widely separated within a 10-kb region and three of them show 75-86% identify with the three known rat gamma GT cDNAs. Although the heterogeneity of the 5' ends of gamma GT RNAs may be explained in part by alternative splicing, it is likely that multiple promoters are involved in their generation.
小鼠γ-谷氨酰转移酶（γGT；EC 2.3.2.2）基因的5'区域已被克隆和分析。该分析与从γGT cDNA克隆获得的序列信息相结合，表明在小鼠中，单个γGT基因编码六种不同的mRNA，它们的5'序列不同。对γGT RNA稳态水平的分析揭示了这些RNA在不同器官中的不同表达模式。六种不同的5'序列在一个10 kb的区域内广泛分离，其中三种与三种已知的大鼠γGT cDNA具有75 - 86%的同一性。尽管γGT RNA 5'端的异质性可能部分由可变剪接解释，但很可能多个启动子参与了它们的产生。
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