Nizhnikh G V, Kononov V P
Arkh Anat Gistol Embriol. 1975 Aug;69(8):96-101.
Under study were effects of triethylenthiophosphoramid (thioTEP) on mature gametes of rabbits, their impregnating capacity and embryonic development. When treated with thioTEP in non-toxic concentration the spermatozoa did not change their mobility, vitality in vitro and impregnation capacity. However, investigation of early postnatal development showed a delay of the beginning of cleavage and death at early stages due to thioTEP effects; the number of formed blastocysts was observed to decrease from 76% to 61%, i.e. by a statistically significant value 15 +/- 6,5%. A greater number of zigotes of delayed development was found in a group of experimental animals (39%), as compared with controls (24%), when females were dissected on the 4th-5th days after impregnation. DNA content in spermatozoa treated with the chem-mutagen remained unchanged.
研究了三亚乙基硫代磷酰胺（硫代TEP）对家兔成熟配子、其受精能力和胚胎发育的影响。当用无毒浓度的硫代TEP处理时，精子的活力、体外生存能力和受精能力没有改变。然而，对出生后早期发育的研究表明，由于硫代TEP的作用，卵裂开始延迟且早期死亡；观察到形成的囊胚数量从76%降至61%，即统计学上显著下降了15±6.5%。与对照组（24%）相比，在受孕后第4 - 5天解剖雌性实验动物时，发现实验组中有更多发育延迟的合子（39%）。经化学诱变剂处理的精子中的DNA含量保持不变。
