Ryba M, Grieb P, Walski M, Sawicki J, Pastuszko M
Department of Neurophysiology, Polish Academy of Sciences Medical Research Center, Warsaw.
Acta Neurochir (Wien). 1993;122(1-2):118-21. doi: 10.1007/BF01446997.
We compared the morphology of the basilar artery walls in rabbits with experimental subarachnoid haemorrhage (SAH) without and with concomitant treatment with a novel immunosuppressive drug, 2-chloro-2'-deoxyadenosine (2 CdA). The treatment was successful in the prevention of the angiopathic changes, most likely due to its ability to inhibit lymphocyte activation in response to mitogenic signals. Since lymphocyte (and monocyte?) activation may play an important role in the development of the delayed neurological deficits in patients following SAH, the use of 2 CdA to prevent these deficits shall be considered.
我们比较了未接受以及接受新型免疫抑制药物2-氯-2'-脱氧腺苷（2 CdA）治疗的实验性蛛网膜下腔出血（SAH）兔基底动脉壁的形态。该治疗成功预防了血管病变，这很可能归因于其抑制淋巴细胞对有丝分裂信号作出反应而活化的能力。由于淋巴细胞（以及单核细胞？）活化可能在SAH患者迟发性神经功能缺损的发生中起重要作用，因此应考虑使用2 CdA来预防这些缺损。
