Abel J L
Department of Psychology, Pennsylvania State University, University Park 16802.
Behav Res Ther. 1993 Jun;31(5):463-78. doi: 10.1016/0005-7967(93)90127-g.
A comprehensive review of controlled investigations examining the effectiveness of exposure with response prevention (ERP) and clomipramine (CMI), as well as other serotonergic anti-depressants, in the treatment of Obsessive Compulsive Disorder (OCD) was conducted. Overall, findings suggested that ERP is more effective than CMI, particularly in alleviating rituals, but CMI may be more effective in reducing obsessive compulsive behavior among individuals with concomitant severe depression, obsessions only, and overvalued ideation. In addition, the literature favors ERP in terms of side-effects and risks, dropout, and maintenance, while one advantage of drug therapy is that less time and effort are required by the therapist and patient. Directions for interdisciplinary treatment are discussed.
对有关暴露与反应阻止疗法（ERP）、氯米帕明（CMI）以及其他血清素能抗抑郁药治疗强迫症（OCD）有效性的对照研究进行了全面综述。总体而言，研究结果表明ERP比CMI更有效，尤其是在减轻仪式行为方面，但CMI在减少伴有严重抑郁症、仅有强迫观念以及超价观念的个体的强迫行为方面可能更有效。此外，在副作用和风险、脱落率以及维持治疗方面，文献更倾向于ERP，而药物治疗的一个优势是治疗师和患者所需的时间和精力较少。文中还讨论了跨学科治疗的方向。
