Vesole D H, Jagannath S, Glenn L, Barlogie B
Department of Medicine, University of Arkansas for Medical Sciences, Little Rock.
Hematol Oncol Clin North Am. 1993 Jun;7(3):613-30.
High-dose chemotherapy with autologous hematopoietic stem cell reconstitution is efficacious in the treatment of multiple myeloma. The various preparative regimens, sources of hematopoietic stem cells, and post-transplant immunomodulation are discussed. Tandem autotransplantation following intravenous melphalan chemotherapy has low morbidity and mortality even in patients with refractory disease. The most encouraging results are observed in patients undergoing high-dose chemotherapy with less prior treatment, lower tumor mass, and sensitive disease.
大剂量化疗联合自体造血干细胞重建对多发性骨髓瘤的治疗有效。文中讨论了各种预处理方案、造血干细胞来源及移植后免疫调节。静脉注射美法仑化疗后的序贯自体移植即使对难治性疾病患者也具有较低的发病率和死亡率。在接受大剂量化疗且先前治疗较少、肿瘤负荷较低及疾病敏感的患者中观察到了最令人鼓舞的结果。
