Lipponen H J, Aaltomaa S, Syrjänen S, Syrjänen K
Department of Pathology, University of Kuopio, Finland.
Anticancer Res. 1993 Jul-Aug;13(4):1147-52.
A series of 193 archival breast cancer biopsies were analysed immunohistochemically to detect over-expression of c-erbB-2 oncoprotein. Altogether, 59/193 (31%) of the tumours were positive for c-erbB-2, the staining being located at the cell membranes with weak cytoplasmic staining in some samples. The expression of c-erbB-2 was positively correlated with a number of parameters analysed: ductal type, intraductal growth pattern, high tumour grade, density of tumour infiltrating lymphocytes (TIL), DNA aneuploidy, steroid (ER, PR) receptor negativity, high S-phase fraction, high mitotic frequency, high values of nuclear factors, and accumulation of p53 protein. c-erbB-2 expression showed a weak association with a low survival probability (p = 0.07) and with a short recurrence-free survival (p = 0.1). In local tumours or in axillary lymph node positive tumours, c-erB-2 expression had no significant prognostic value. Also in multivariate analysis, c-erbB-2 expression had no independent prognostic value superior to the axillary lymph node status, tumour diameter and mitotic frequency. The results show that c-erbB-2 expression in related to several histopathological features of malignancy and cell proliferation in breast cancer, but it has no independent prognostic value better than that of the established prognostic factors.
对193份存档的乳腺癌活检样本进行免疫组织化学分析，以检测c-erbB-2癌蛋白的过表达情况。总共193例肿瘤中有59例（31%）c-erbB-2呈阳性，染色位于细胞膜，部分样本细胞质染色较弱。c-erbB-2的表达与所分析的一些参数呈正相关：导管类型、导管内生长模式、高肿瘤分级、肿瘤浸润淋巴细胞（TIL）密度、DNA非整倍体、类固醇（ER、PR）受体阴性、高S期分数、高有丝分裂频率、高核因子值以及p53蛋白的积累。c-erbB-2表达与低生存率（p = 0.07）和短无复发生存期（p = 0.1）呈弱相关。在局部肿瘤或腋窝淋巴结阳性肿瘤中，c-erB-2表达无显著预后价值。在多因素分析中，c-erbB-2表达也没有优于腋窝淋巴结状态、肿瘤直径和有丝分裂频率的独立预后价值。结果表明，c-erbB-2表达与乳腺癌的几种恶性组织病理学特征和细胞增殖相关，但它没有比既定预后因素更好的独立预后价值。
