Efferth T, Dunn T A, Berlion M, Langenbahn H, Pommerenke E W, Volm M
German Cancer Research Center, Heidelberg.
Anticancer Res. 1993 Jul-Aug;13(4):905-8.
In a panel of 14 primary cultures of human renal cell carcinomas the reversal of inherent multidrug-resistance by S 9788, a new triazinoaminopiperidine derivative, was analysed. In combination with doxorubicin S 9788 revealed an evident reversal of multidrug resistance in 12 cell cultures. Two cell cultures remained unaffected. An association between reversal and P-glycoprotein (P-170) expression suggests that S 9788 exerts its activity through P-glycoprotein.
在一组14种人肾细胞癌原代培养物中，分析了一种新型三嗪氨基哌啶衍生物S 9788对固有多药耐药性的逆转作用。与阿霉素联合使用时，S 9788在12种细胞培养物中显示出明显的多药耐药逆转作用。两种细胞培养物未受影响。逆转作用与P-糖蛋白（P-170）表达之间的关联表明，S 9788通过P-糖蛋白发挥其活性。
