Izenwasser S, Katz J L
Psychobiology Section, NIDA Addiction Research Center, Baltimore, MD.
Eur J Pharmacol. 1993 Jun 15;246(1):39-44. doi: 10.1016/0922-4106(93)90007-v.
Adenylyl cyclase activity was stimulated by dopamine to approximately 200% over basal activity in both squirrel monkey caudate and rat caudate-putamen. The selective dopamine D1 receptor agonists SKF 82958, A68930, dihydrexidine, CY 208-243, and SKF 75670 each produced similar maximal stimulation across the two species. SKF 38393, SKF 81297, and 6-Br-APB, however, each had higher efficacy in rat than in monkey. These results suggest differences in dopamine D1 receptors in the two species.
在松鼠猴尾状核和大鼠尾状核-壳核中，多巴胺可将腺苷酸环化酶活性刺激至比基础活性高约200%。选择性多巴胺D1受体激动剂SKF 82958、A68930、二氢麦角隐亭、CY 208-243和SKF 75670在这两个物种中均产生了相似的最大刺激作用。然而，SKF 38393、SKF 81297和6-溴-APB在大鼠中的效力均高于猴子。这些结果表明这两个物种的多巴胺D1受体存在差异。
