麻醉性类固醇——综述
Anaesthetic steroids--a review.
作者信息
Kumar V L, Malhotra J, Kumar V
机构信息
Department of Pharmacology, All India Institute of Medical Sciences, New Delhi.
出版信息
Indian J Med Sci. 1993 Apr;47(4):87-95.
PMID:8102618
Abstract
Steroids produce anaesthesia besides producing the well known metabolic and hormonal effects. A number of anaesthetic steroids have been synthesized and tried clinically. Hydroxydione, althesin, minaxolone and pregnanolone are among those studied in detail. They act through GABAergic mechanism and are known to be advantageous over barbiturates.
摘要
类固醇除了产生众所周知的代谢和激素作用外，还能产生麻醉作用。已经合成了多种麻醉性类固醇并进行了临床试用。羟二酮、阿法沙龙、米那索龙和孕烷醇酮都在详细研究之列。它们通过γ-氨基丁酸能机制发挥作用，并且已知比巴比妥类药物更具优势。
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