新加坡华裔、马来裔和印度裔基于Hae III的限制性片段长度多态性（RFLP）系统中DNA图谱数据库的开发。
The development of DNA profiling database in an HAE III based RFLP system for Chinese, Malays, and Indians in Singapore.
作者信息
Chow S T, Tan W F, Yap K H, Ng T L
机构信息
Department of Scientific Services, Institute of Science and Forensic Medicine, Singapore.
出版信息
J Forensic Sci. 1993 Jul;38(4):874-84.
Deoxyribonucleic acid (DNA) restriction fragment length polymorphism (RFLP) profiles were obtained for blood specimens from the three population groups--Chinese, Malays and Indians--in Singapore. The population databases were collected from Hae III digested high molecular weight DNA hybridized with four variable number of tandem repeats (VNTR) loci--D2S44, D10S28, D4S139 and D1S7. The data were analyzed statistically using the fixed bin system. Comparison of ratio of bin frequencies of these population data with published data on whites, blacks, and hispanics shows that the alleleic distribution at these loci is not seriously different among the six groups. This has important implications to the statistical significance of forensic DNA applications.
获得了来自新加坡三个族群——华人、马来人和印度人——血液样本的脱氧核糖核酸（DNA）限制性片段长度多态性（RFLP）图谱。群体数据库收集自经Hae III消化的高分子量DNA，这些DNA与四个可变串联重复序列（VNTR）位点——D2S44、D10S28、D4S139和D1S7——杂交。使用固定分类系统对数据进行统计分析。将这些群体数据的分类频率比与已发表的关于白人、黑人和西班牙裔的数据进行比较，结果表明这六个群体在这些位点的等位基因分布没有显著差异。这对法医DNA应用的统计学意义具有重要影响。
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