葡萄胎中的人类白细胞抗原
Human leukocyte antigen in hydatidiform mole.
作者信息
Souka A R, Kholeif A, Zaki S, Rocca M, Ghanem I
机构信息
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Alexandria, Egypt.
出版信息
Int J Gynaecol Obstet. 1993 Jun;41(3):257-60. doi: 10.1016/0020-7292(93)90552-8.
OBJECTIVE
To find any possible association between human leukocyte antigen (HLA) as a genetic marker and the development of hydatidiform mole (HM).
METHOD
The lymphocyte microtoxicity technique was used to study the HLA antigens in 3 groups: 18 women with hydatidiform mole and their husbands (study group), 300 normal women (first control group), and 20 normal pregnant women and their husbands (second control group).
RESULT
Hydatidiform mole is more frequent in women having HLA A1. The disease is more common in couples with partial compatibility of the B locus.
CONCLUSION
HM occurs more frequently in women with certain HLA antigens and when the husband and wife have partial compatibility at the B locus.
目的
寻找作为遗传标记的人类白细胞抗原（HLA）与葡萄胎（HM）发生之间的任何可能关联。
方法
采用淋巴细胞微毒性技术研究三组中的HLA抗原：18例葡萄胎患者及其丈夫（研究组）、300例正常女性（第一对照组）、20例正常孕妇及其丈夫（第二对照组）。
结果
HLA A1型女性患葡萄胎更为常见。该疾病在B位点部分相容的夫妇中更为普遍。
结论
具有某些HLA抗原的女性以及夫妻在B位点部分相容时，葡萄胎的发生更为频繁。
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