Shiratori K, Watanabe S, Takeuchi T
Department of Medicine and Gastroenterology, Tokyo Women's Medical College, Japan.
Digestion. 1993;54(3):163-7. doi: 10.1159/000201032.
We investigated the effect of indomethacin on secretin- and somatostatin-induced inhibition of gastric acid secretion stimulated by intravenous infusion of pentagastrin (0.3 microgram/kg.h) in anesthetized rats. Intravenous administration of a prostaglandin synthesis inhibitor, indomethacin (2 mg/kg + 1 mg/kg.h), completely abolished the inhibition of gastric acid secretion induced by intravenous infusion of secretion (0.05 CU/kg.h). The inhibitory effect of intravenous infusion of somatostatin (Sandostatin; 0.2 micrograms/kg.h). The inhibitory the gastric acid was not significantly changed by indomethacin. Secretin significantly increased the gastric mucosal content of prostaglandin E2, and the increase was completely blocked by indomethacin. Somatostatin, however, had no significant effect on gastric mucosal prostaglandin E2. The results suggest that endogenous prostaglandin is involved in the mechanism of inhibition of gastric acid secretion by secretin, but not by somatostatin.
我们研究了吲哚美辛对麻醉大鼠静脉输注五肽胃泌素（0.3微克/千克·小时）刺激的胃酸分泌的影响，该胃酸分泌受促胰液素和生长抑素抑制。静脉给予前列腺素合成抑制剂吲哚美辛（2毫克/千克 + 1毫克/千克·小时），完全消除了静脉输注促胰液素（0.05 CU/千克·小时）诱导的胃酸分泌抑制作用。静脉输注生长抑素（善宁；0.2微克/千克·小时）的抑制作用。吲哚美辛对胃酸的抑制作用没有显著改变。促胰液素显著增加胃黏膜前列腺素E2的含量，且该增加被吲哚美辛完全阻断。然而，生长抑素对胃黏膜前列腺素E2没有显著影响。结果表明，内源性前列腺素参与促胰液素抑制胃酸分泌的机制，但不参与生长抑素抑制胃酸分泌的机制。
