Kasai H, Jinno Y, Kaneta S, Fukata Y, Fukushima H, Ogawa N
Pharmaceutical Research Laboratory, Kirin Brewery Co. Ltd, Gunma, Japan.
J Pharm Pharmacol. 1993 Jun;45(6):573-5. doi: 10.1111/j.2042-7158.1993.tb05602.x.
The present study was performed to determine whether KRN2391 (N-cyano-N'-(2-nitroxyethyl)-3-pyridinecarboximidamide monomethanesulphonate), a novel vasodilator, shows different effects on porcine isolated coronary arteries of different sizes. The vasodilating effects of KRN2391 on porcine large (2.5-3.0 mm outer diam.) and small (0.8-1.0 mm) coronary arteries were also compared with those of cromakalim, nicorandil, nifedipine, nitroglycerin and adenosine. The relaxant effects of these drugs were examined in coronary arteries contracted by 25 mM KCl. Nitroglycerin caused greater relaxation in large vessels than in small vessels. In contrast, adenosine, nifedipine and cromakalim caused greater relaxation in small vessels. However, there was no difference between large and small vessels in the relaxing effects of KRN2391 and nicorandil. These unique features of KRN2391 and nicorandil appear to be beneficial in ischaemic heart disease.
本研究旨在确定新型血管扩张剂KRN2391（N-氰基-N'-（2-硝氧乙基）-3-吡啶甲脒单甲磺酸盐）对不同大小的猪离体冠状动脉是否具有不同作用。还将KRN2391对猪大（外径2.5 - 3.0 mm）、小（0.8 - 1.0 mm）冠状动脉的血管舒张作用与克罗卡林、尼可地尔、硝苯地平、硝酸甘油和腺苷的作用进行了比较。在由25 mM氯化钾收缩的冠状动脉中检测了这些药物的舒张作用。硝酸甘油在大血管中引起的舒张作用大于小血管。相反，腺苷、硝苯地平和克罗卡林在小血管中引起的舒张作用更大。然而，KRN2391和尼可地尔的舒张作用在大、小血管之间没有差异。KRN2391和尼可地尔的这些独特特性似乎对缺血性心脏病有益。
