合成胸腺生成素对α-银环蛇毒素与大鼠神经膜结合的影响。
The effects of synthetic thymopoietin on binding of alpha-bungarotoxin to rat neural membranes.
作者信息
Jennings K R, Shieh H M
机构信息
Department of Biology, York University, North York, Ontario, Canada.
出版信息
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1993 Mar;104(3):411-3. doi: 10.1016/0742-8413(93)90010-i.
PMID:8103433
Abstract
Chemically synthesized bovine thymopoietin I (TPO-I) and thymopoietin II (TPO-II) were evaluated as inhibitors of 125I alpha-Bungarotoxin binding to rat brain neural membranes and found to be over 1,000 x less potent (IC50 = 10 microM) than reported for thymopoietin isolated from bovine thymus.
摘要
对化学合成的牛胸腺生成素I（TPO-I）和胸腺生成素II（TPO-II）作为125Iα-银环蛇毒素与大鼠脑神经网络膜结合的抑制剂进行了评估，发现其效力比从牛胸腺中分离出的胸腺生成素低1000倍以上（IC50 = 10 microM）。
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