地塞米松对两种仓鼠品系金黄仓鼠和灰仓鼠肝脏细胞色素P450IIIA亚家族的影响。

Effects of dexamethasone on the hepatic cytochrome P450IIIA subfamily in two hamster strains Mesocricetus auratus and Cricetus griseus.

Antignac E, Fukuhara M, Kimura M

Department of Pharmaceutical Sciences, National Institute of Public Health, Tokyo, Japan.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1993 Mar;104(3):433-7. doi: 10.1016/0742-8413(93)90014-c.

Abstract

Administration of dexamethasone significantly reduced the amount of hepatic cytochrome P450 in Syrian golden and Chinese hamsters, while it increased the amount in rats. 2. In contrast to rats, the induction rate of the activities of erythromycin and troleandomycin N-demethylases by dexamethasone was relatively low, while that of the testosterone 6 beta-hydroxylase was high in the two hamster strains. 3. Western blot analysis revealed that dexamethasone did not modify markedly the pattern of the P450IIIA subfamily proteins in the two hamster strains.

摘要

地塞米松的给药显著降低了叙利亚金黄地鼠和中国仓鼠肝脏细胞色素P450的含量，而在大鼠中却使其含量增加。2. 与大鼠不同，地塞米松对红霉素和醋竹桃霉素N-脱甲基酶活性的诱导率相对较低，而对两种仓鼠品系中睾酮6β-羟化酶的诱导率较高。3. 蛋白质免疫印迹分析表明，地塞米松并未显著改变两种仓鼠品系中P450IIIA亚家族蛋白的模式。