Hashimoto S, Imai K, Kobayashi T, Amemiya E, Takahashi Y, Tomita Y, Iwata T, Suguro H, Yamaguchi M, Yachi A
First Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
Allergy. 1993 Jul;48(5):370-2. doi: 10.1111/j.1398-9995.1993.tb02408.x.
We measured the levels of soluble intercellular adhesion molecule-1 (sICAM-1) in sera from patients with bronchial asthma. sICAM-1 levels in sera from atopic asthmatic patients in stable conditions were higher than in normal control subjects. Furthermore, the sICAM-1 levels in sera obtained during bronchial asthma attacks were higher than those in sera obtained in stable conditions. These results suggest that higher levels of sICAM-1 in sera reflect the upregulation of ICAM-1 expression in allergic inflammation.
我们检测了支气管哮喘患者血清中可溶性细胞间黏附分子-1（sICAM-1）的水平。处于稳定状态的特应性哮喘患者血清中的sICAM-1水平高于正常对照受试者。此外，支气管哮喘发作期间采集的血清中的sICAM-1水平高于稳定状态下采集的血清中的水平。这些结果表明，血清中较高水平的sICAM-1反映了变应性炎症中ICAM-1表达的上调。
