Holm R, Abeler V M, Skomedal H, Nesland J M
Department of Pathology, Norwegian Radium Hospital, Oslo.
Zentralbl Pathol. 1993 Jun;139(2):153-6.
Twenty-eight primary small cell carcinomas of the cervix uteri were examined immunohistochemically for overexpression of p53 protein and c-erbB-2 protein. Twenty-one per cent of the cases showed positive immunostaining for p53 protein, whereas no staining was observed using the antibody against c-erbB-2. Our results indicate that altered expression of p53 protein may be involved in the development of small cell carcinoma of the cervix uteri.
对28例原发性子宫颈小细胞癌进行免疫组织化学检查，以检测p53蛋白和c-erbB-2蛋白的过表达情况。21%的病例p53蛋白免疫染色呈阳性，而使用抗c-erbB-2抗体未观察到染色。我们的结果表明，p53蛋白表达改变可能参与子宫颈小细胞癌的发生发展。
