组胺：其在乳腺中的代谢与定位

Histamine: its metabolism and localization in mammary gland.

Maslinski C, Kierska D, Fogel W A, Kinnunen A, Panula P

Department of Biogenic Amines, Polish Academy of Sciences, Lodz.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1993 Jun;105(2):269-73. doi: 10.1016/0742-8413(93)90206-z.

Abstract

Mammary gland of mouse (Mus musculus), rat (Rattus rattus), guinea pig (Cavia porcellus), cow (Bos taurus) and pig (Sus scrofa) contains different but always high concentrations of histamine. 2. Generally, the tissue histamine is localized in mast cells, although non-mast cell histamine immunoreactivity is also present in mammary glands of the mouse, cow and pig. No histamine immunoreactive nerves could be detected. 3. Mammary glands are able to synthesize and inactivate histamine; the activity of specific histidine decarboxylase and at least one of the catabolizing enzyme could be demonstrated. 4. Histamine fulfils basic criteria for being involved in physiological function of mammary glands.

摘要

小鼠（小家鼠）、大鼠（褐家鼠）、豚鼠（豚鼠）、牛（黄牛）和猪（野猪）的乳腺含有不同但始终较高浓度的组胺。2. 一般来说，组织中的组胺定位于肥大细胞，尽管在小鼠、牛和猪的乳腺中也存在非肥大细胞组胺免疫反应性。未检测到组胺免疫反应性神经。3. 乳腺能够合成和灭活组胺；可以证明特异性组氨酸脱羧酶和至少一种分解代谢酶的活性。4. 组胺符合参与乳腺生理功能的基本标准。