芬太尼、氯胺酮及氟芬合剂对乙醇处理和未处理犬某些生化参数的影响。

Effect of fentanyl, ketamine and thalamonal on some biochemical parameters in ethanol-treated and untreated dogs.

作者信息

Gvozdenović L V, Popović M R, Jakovljević V S, Lukić V

机构信息

Faculty of Medicine, Institute of Surgery, Novi Sad, Yugoslavia.

出版信息

Hum Exp Toxicol. 1993 Jul;12(4):279-83. doi: 10.1177/096032719301200404.

DOI:10.1177/096032719301200404

PMID:8104004

Abstract

The effects of fentanyl, ketamine and thalamonal on some biochemical parameters of ethanol-treated and untreated dogs, were studied. The study was carried out on mongrel dogs. The animals were divided into two main groups: one which had free access to food and to 12% (v/v) ethanol, instead of water, and a control group which had food and water ad libitum. The animals in both groups were exposed to the action of anaesthetics for 3 h. The results show that, under the given experimental conditions, the anaesthetics did not significantly change the investigated parameters of blood and liver, either in ethanol-treated or untreated dogs. However, the action of ethanol caused remarkable changes in almost all the investigated parameters. An increased content of cytochrome P450 caused by the action of ethanol suggests possible changes in the metabolism of anaesthetics, which should be of concern to anaesthetists when dealing with patients potentially intoxicated with ethanol.

摘要

研究了芬太尼、氯胺酮和速眠安对经乙醇处理和未经乙醇处理犬的一些生化参数的影响。该研究在杂种犬身上进行。动物被分为两个主要组：一组可以自由获取食物和12%（v/v）乙醇而非水，另一组为自由摄食和饮水的对照组。两组动物均接受3小时麻醉剂作用。结果表明，在给定实验条件下，麻醉剂在经乙醇处理或未经乙醇处理的犬中均未显著改变所研究的血液和肝脏参数。然而，乙醇的作用几乎使所有研究参数都发生了显著变化。乙醇作用导致细胞色素P450含量增加，这表明麻醉剂代谢可能发生变化，麻醉医生在处理可能乙醇中毒的患者时应予以关注。