白细胞介素12增强毛细胞白血病中自然杀伤细胞介导的细胞毒性。
Interleukin 12 augments natural killer-cell mediated cytotoxicity in hairy cell leukemia.
作者信息
Bigda J, Mysliwska J, Dziadziuszko R, Bigda J, Mysliwski A, Hellmann A
机构信息
Department of Histology and Hematology, Medical School, Gdansk, Poland.
出版信息
Leuk Lymphoma. 1993 May;10(1-2):121-5. doi: 10.3109/10428199309147365.
Interleukin 12 (IL12, NKSF-natural killer stimulatory factor) was found to stimulate natural killer (NK) cell activity of hairy cell leukemia (HCL) patients. Two patients not responding to IL12 stimulation were also resistant to interferon alpha (IFN alpha)-mediated augmentation of NK activity. IL12 also enhanced slightly the interleukin 2 (IL2)-induced cytotoxicity of HCL patients, while IFN alpha reduced the stimulatory effect of IL2. These data suggest that interleukin 12 has NK modulatory properties in HCL leukemia patients, which may be different from those of IFN alpha.
白细胞介素12（IL12，NKSF - 自然杀伤细胞刺激因子）被发现可刺激毛细胞白血病（HCL）患者的自然杀伤（NK）细胞活性。两名对IL12刺激无反应的患者也对干扰素α（IFNα）介导的NK活性增强具有抗性。IL12还略微增强了HCL患者白细胞介素2（IL2）诱导的细胞毒性，而IFNα则降低了IL2的刺激作用。这些数据表明，白细胞介素12在HCL白血病患者中具有NK调节特性，这可能与干扰素α的特性不同。
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