Antón F, Labarga P, Pinilla J, Soto M J, Leoz A, del Cura J, Borque L, Milazzo A
Sección de Medicina Interna, Central Hospital San Millán INSALUD, Logroño.
Enferm Infecc Microbiol Clin. 1993 Aug-Sep;11(7):373-7.
The aim of the present study was to evaluate the relation between the number of CD4 lymphocytes, the CD4/CD8 ratio and the plasma levels of neopterin and beta-2 microglobulin, and the clinical status, risk of progression without of active opportunistic infections, among HIV-infected patients.
Seventy-two patients infected by HIV in different clinical groups were evaluated upon entering the study and following a mean follow up of 6 months for the parameters studied.
The values of CD4 lymphocytes and neopterin were related with the clinical status according to the CDC's classification, with no significant differences existing in the beta-2 microglobulin level. The CD4 count as well as the neopterin and the beta-2 microglobulin levels differed significantly when classified to the patients with regard to the risk of progression to AIDS throughout the study. The presence of active opportunistic infections was related with significantly higher concentrations of neopterin without differences recorded for the remaining parameters.
The parameters studied are good markers or both clinical status and/or the risk of short-term progression to AIDS. Neopterin levels are high during acute infections. Therefore, its prognostic value should be cautiously evaluated in this situation.
本研究旨在评估HIV感染患者体内CD4淋巴细胞数量、CD4/CD8比值、新蝶呤和β2微球蛋白血浆水平之间的关系，以及临床状况、无活动性机会性感染时的疾病进展风险。
对72例处于不同临床组的HIV感染患者在进入研究时以及对所研究参数进行平均6个月的随访后进行评估。
根据美国疾病控制与预防中心（CDC）的分类，CD4淋巴细胞和新蝶呤的值与临床状况相关，β2微球蛋白水平无显著差异。在整个研究过程中，根据进展为艾滋病的风险对患者进行分类时，CD4细胞计数以及新蝶呤和β2微球蛋白水平存在显著差异。活动性机会性感染的存在与新蝶呤浓度显著升高相关，其余参数无差异。
所研究的参数是临床状况和/或短期进展为艾滋病风险的良好标志物。急性感染期间新蝶呤水平较高。因此，在这种情况下应谨慎评估其预后价值。
