• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Monitoring of benzodiazepines (clobazam, diazepam and their main active metabolites) in human plasma by column-switching high-performance liquid chromatography.

作者信息

Lacroix C, Wojciechowski F, Danger P

机构信息

Laboratoire de Pharmacocinétique, Centre Hospitalier, Le Havre, France.

出版信息

J Chromatogr. 1993 Aug 11;617(2):285-90. doi: 10.1016/0378-4347(93)80500-4.

DOI:10.1016/0378-4347(93)80500-4
PMID:8104951
Abstract

A column-switching high-performance liquid chromatographic method for the simultaneous determination of clobazam, diazepam and their main metabolites in human plasma is described. A 200-microliters plasma sample was directly injected into a precolumn filled with TSK-gel PW. After a washing step with potassium phosphate buffer, the retained substances were backflushed into a reversed-phase column with a mobile phase of acetonitrile-phosphate buffer-diethylamine. Various drugs frequently co-administered with clobazam or diazepam do not interfere with the determination.

摘要

相似文献

1
Monitoring of benzodiazepines (clobazam, diazepam and their main active metabolites) in human plasma by column-switching high-performance liquid chromatography.
J Chromatogr. 1993 Aug 11;617(2):285-90. doi: 10.1016/0378-4347(93)80500-4.
2
Simultaneous determination of clobazam, N-desmethyl clobazam and clonazepam in plasma by high performance liquid chromatography.
Ther Drug Monit. 1987;9(1):113-6. doi: 10.1097/00007691-198703000-00019.
3
Liquid chromatography determination of clobazam and its major metabolite N-desmethylclobazam in human plasma.
Ther Drug Monit. 1982;4(3):301-5. doi: 10.1097/00007691-198208000-00009.
4
The analysis of clobazam and its metabolite desmethylclobazam by high-performance liquid chromatography.
Ther Drug Monit. 1991 Jul;13(4):339-44. doi: 10.1097/00007691-199107000-00010.
5
Analysis of clobazam and its active metabolite norclobazam in plasma and serum using HPLC/DAD.
Scand J Clin Lab Invest. 1996 Nov;56(7):609-14. doi: 10.3109/00365519609090595.
6
High-performance liquid chromatographic method for the determination of benzodiazepines in plasma or serum using the column-switching technique.采用柱切换技术测定血浆或血清中苯二氮䓬类药物的高效液相色谱法。
J Chromatogr B Biomed Sci Appl. 2000 Jun 9;742(2):381-90. doi: 10.1016/s0378-4347(00)00185-7.
7
Quantitation of clobazam in human plasma using high-performance liquid chromatography.
J Chromatogr Sci. 1999 May;37(5):145-9. doi: 10.1093/chromsci/37.5.145.
8
Optimised determination of clobazam in human plasma with extraction and high-performance liquid chromatography analysis.
J Chromatogr B Biomed Sci Appl. 2001 Jan 5;750(1):177-80. doi: 10.1016/s0378-4347(00)00440-0.
9
Determination of clobazam, N-desmethylclobazam and their hydroxy metabolites in plasma and urine by high-performance liquid chromatography.
J Chromatogr. 1985 Oct 11;343(2):369-77. doi: 10.1016/s0378-4347(00)84605-8.
10
Simultaneous determination of twelve benzodiazepines in human serum using a new reversed-phase chromatographic column on a 2-microns porous microspherical silica gel.使用新型反相色谱柱在2微米多孔微球硅胶上同时测定人血清中的十二种苯二氮卓类药物。
J Chromatogr B Biomed Appl. 1996 Jun 28;682(1):173-8. doi: 10.1016/0378-4347(96)00121-1.