Frishman W H, Landau A, Cretkovic A
Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY.
J Clin Pharmacol. 1993 Aug;33(8):752-5. doi: 10.1002/j.1552-4604.1993.tb05619.x.
Calcium-channel blockers have been shown to be both safe and effective for treatment of patients with systemic hypertension. These drugs reduce peripheral vascular resistance predominantly by the inhibition of transmembrane calcium ion fluxes in vascular smooth muscle, and by this mechanism can reduce elevated blood pressure. To maximize blood pressure lowering efficacy in patients, calcium-channel blockers have also been used in combination with other antihypertensive treatments that have included diuretics, beta-adrenergic blockers, and angiotensin-converting enzyme inhibitors.
钙通道阻滞剂已被证明对于治疗系统性高血压患者既安全又有效。这些药物主要通过抑制血管平滑肌中的跨膜钙离子通量来降低外周血管阻力，并通过这种机制降低升高的血压。为了使患者的降压效果最大化，钙通道阻滞剂还与其他抗高血压治疗联合使用，这些治疗包括利尿剂、β-肾上腺素能阻滞剂和血管紧张素转换酶抑制剂。
