室周核损伤可调节不同脑区及垂体前叶中特异性生长抑素结合。

Periventricular nucleus lesioning modulates specific somatostatin binding in various brain regions and anterior pituitary.

作者信息

Sabry I, Suzuki M, Shigematsu K, Kakegawa T

机构信息

Zoology Department, Faculty of Science, Alexandria University, Egypt.

出版信息

J Exp Zool. 1993 Oct 1;267(2):171-9. doi: 10.1002/jez.1402670210.

DOI:10.1002/jez.1402670210

PMID:8105022

Abstract

The effects of periventricular nucleus (Pe) lesioning on the plasma growth hormone (GH) levels and the anterior pituitary (A.P.) and brain somatostatin (SRIF) receptors were studied. A transient significant increase in plasma GH level in lesioned rats was detected 1 day after the operation. This elevated level of plasma GH started to decrease 3 days after lesioning. These changes were paralleled by an increase in binding of 125I-Tyr11-SRIF-14 to the A.P. 1 day after lesioning. This result could further confirm that the SRIF inhibitory action on GH release takes place at the A.P. level. Also, a transient increase in binding of the radioligand was detected in some brain areas 1 and 4 days after the lesion. However, the mechanism by which this increase takes place remains to be elucidated.

摘要

研究了室周核（Pe）损伤对血浆生长激素（GH）水平、垂体前叶（A.P.）和脑生长抑素（SRIF）受体的影响。术后1天，在损伤大鼠中检测到血浆GH水平短暂显著升高。损伤后3天，血浆GH水平开始下降。这些变化与损伤后1天125I-Tyr11-SRIF-14与垂体前叶结合增加相平行。这一结果进一步证实了生长抑素对GH释放的抑制作用发生在垂体前叶水平。此外，损伤后1天和4天，在一些脑区检测到放射性配体结合短暂增加。然而，这种增加发生的机制仍有待阐明。