Cross S E, Roberts M S
Department of Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia.
J Pharm Pharmacol. 1993 Jul;45(7):606-9. doi: 10.1111/j.2042-7158.1993.tb05661.x.
The subcutaneous absorption and consequent tissue distribution of interferon g was studied in an anaesthetized rat model. Interferon g showed a biphasic disappearance profile from a solution in a subcutaneous absorption cell. Both the initial rapid distribution phase and slower removal phase followed first order kinetics. The steady-state clearance of interferon g from the cell was 1.41 +/- 0.38 x 10(-3) mL min-1, and the absorption half-life (t1/2) was 3.8 +/- 1.1 h (n = 4). Noradrenaline did not significantly alter either the clearance or absorption of interferon g (1.18 +/- 0.44 x 10(-3) mL min-1, P > 0.05, absorption t1/2 4.96 +/- 1.9 h, P > 0.05). Given that the clearance of smaller solutes, such as tritiated water, is significantly reduced when noradrenaline is coadministered, it is suggested that interferon g is removed via the lymphatic system rather than by the local blood supply. The amount of interferon g recovered in the plasma, urine and muscle is minimal relative to other solutes where the recovery is almost complete.
在麻醉大鼠模型中研究了干扰素γ的皮下吸收及其随后的组织分布。干扰素γ在皮下吸收池中从溶液中呈现出双相消失曲线。初始快速分布阶段和较慢清除阶段均遵循一级动力学。干扰素γ从细胞中的稳态清除率为1.41±0.38×10⁻³ mL min⁻¹，吸收半衰期（t1/2）为3.8±1.1小时（n = 4）。去甲肾上腺素对干扰素γ的清除率或吸收均无显著影响（1.18±0.44×10⁻³ mL min⁻¹，P>0.05，吸收t1/2为4.96±1.9小时，P>0.05）。鉴于当同时给予去甲肾上腺素时，较小溶质如氚标记水的清除率会显著降低，提示干扰素γ是通过淋巴系统而非局部血液供应清除的。相对于其他溶质几乎完全回收而言，血浆、尿液和肌肉中回收的干扰素γ量极少。
