Hongo K, Kobayashi S
Department of Neurosurgery, Shinshu University School of Medicine, Matsumoto, Japan.
Neurol Res. 1993 Aug;15(4):218-24. doi: 10.1080/01616412.1993.11740140.
Cerebral vasospasm and/or delayed ischaemic state following subarachnoid haemorrhage still remain unsolved serious problems. With the development and introduction of calcium antagonists as well as the advances in perioperative management, however, the clinical outcome has much improved in recent years. Among such drugs, nimodipine and nicardipine are those, of which effectiveness on the vasospasm or delayed ischaemic changes was demonstrated by several double-blind placebo-controlled studies. This paper reviews the current status of the calcium antagonists used in the management of subarachnoid haemorrhage, focusing mainly on the clinical study.
蛛网膜下腔出血后的脑血管痉挛和/或迟发性缺血状态仍然是尚未解决的严重问题。然而，随着钙拮抗剂的开发和应用以及围手术期管理的进展，近年来临床结果有了很大改善。在这类药物中，尼莫地平和尼卡地平通过多项双盲安慰剂对照研究证明了其对血管痉挛或迟发性缺血性变化的有效性。本文综述了用于蛛网膜下腔出血管理的钙拮抗剂的现状，主要侧重于临床研究。
