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气道平滑肌中的钾通道：两种通道的故事。

Potassium channels in airway smooth muscle: a tale of two channels.

作者信息

Kotlikoff M I

机构信息

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104-6046.

出版信息

Pharmacol Ther. 1993;58(1):1-12. doi: 10.1016/0163-7258(93)90064-k.

DOI:10.1016/0163-7258(93)90064-k
PMID:8105495
Abstract

Potassium channels are an important determinant of smooth muscle excitability and force generation. Two potassium channels have been fully described in airway smooth muscle: large conductance, calcium-activated potassium channels and voltage-dependent delayed rectifier channels. This article will review the biophysics and pharmacology of these channels and discuss what is currently known with respect to their regulation and physiological significance.

摘要

钾通道是平滑肌兴奋性和力量产生的重要决定因素。在气道平滑肌中已充分描述了两种钾通道：大电导钙激活钾通道和电压依赖性延迟整流通道。本文将综述这些通道的生物物理学和药理学，并讨论目前关于它们的调节和生理意义的已知情况。

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