Schröder J, Geider F J, Sauer H
Department of Psychiatry, University of Heidelberg, Germany.
Br J Psychiatry Suppl. 1993 Sep(21):13-5.
The relationship between early treatment response and CT variables was investigated in 50 consecutively admitted patients with DSM-III schizophrenia. Treatment response was defined as the absolute BPRS improvement during patients' hospital stay and was found to be significantly correlated (P < 0.05) with the frontal horn ratio (r = -0.36), ventricular ratio (r = -0.32), width of the third ventricle (r = -0.37), width of the frontal interhemispheric fissure (r = -0.33), and average width of the three largest cortical sulci (r = -0.46). According to the results of multiple regression analysis, 35% of the variance in the treatment response was accounted for by the average width of the three largest cortical sulci, the ventricular ratio and the frontal horn ratio. Thus, cerebral abnormalities associated with poor treatment response do not seem to be limited to one particular morphological site, but involve different brain regions.
对50例连续收治的DSM-III精神分裂症患者的早期治疗反应与CT变量之间的关系进行了研究。治疗反应定义为患者住院期间简明精神病评定量表（BPRS）的绝对改善情况，结果发现其与额角比率（r = -0.36）、脑室比率（r = -0.32）、第三脑室宽度（r = -0.37）、额叶半球间裂宽度（r = -0.33）以及三个最大脑沟的平均宽度（r = -0.46）显著相关（P < 0.05）。根据多元回归分析结果，治疗反应差异的35%可由三个最大脑沟的平均宽度、脑室比率和额角比率来解释。因此，与治疗反应不佳相关的脑异常似乎并不局限于某一特定形态学部位，而是涉及不同脑区。
