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孕酮代谢产物5α-孕烷-3α-醇-20-酮可减少钾离子诱导的大鼠海马中特定神经末梢释放γ-氨基丁酸（GABA）和谷氨酸：一项半定量免疫细胞化学研究。

The progesterone metabolite 5 alpha-pregnan-3 alpha-ol-20-one reduces K(+)-induced GABA and glutamate release from identified nerve terminals in rat hippocampus: a semiquantitative immunocytochemical study.

作者信息

Taubøll E, Ottersen O P, Gjerstad L

机构信息

Department of Neurology, Rikshospitalet, National Hospital, University of Oslo, Norway.

出版信息

Brain Res. 1993 Oct 1;623(2):329-33. doi: 10.1016/0006-8993(93)91448-2.

DOI:10.1016/0006-8993(93)91448-2
PMID:8106124
Abstract

5 alpha-Pregnan-3 alpha ol-20-one (3 alpha-OH-DHP) reduced the depolarization-induced loss of GABA and, to a lesser extent, the glutamate-like immunoreactivities from nerve terminals in the in vitro hippocampal slice. Phenobarbital (PB) had similar effects. These results suggest that 3 alpha-OH-DHP affects presynaptic transmitter release, possibly in a barbiturate-like manner.

摘要

5α-孕烷-3α-醇-20-酮（3α-羟基二氢孕酮，3α-OH-DHP）减少了去极化诱导的γ-氨基丁酸（GABA）丢失，并且在较小程度上减少了体外海马切片中神经末梢的谷氨酸样免疫反应性。苯巴比妥（PB）也有类似作用。这些结果表明，3α-OH-DHP可能以类似巴比妥酸盐的方式影响突触前递质释放。

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