Raynor A C, Sowden D
J Surg Oncol. 1975;7(6):435-45. doi: 10.1002/jso.2930070602.
Medullary thyroid carcinoma is an infrequent and unusual malignancy. Since its description 15 years ago, many new features have developed. Many biologically active compounds which are directly related to the different symptoms of the disease have been recovered from the tumors. A familial incidence is noted, and there is an increased association with other tumors and their behavior. The cell of origin is the parafollicular cell, which secretes calcitonin and is responsible for the unusual behavior of medullary thyroid carcinoma. Treatment is primiarily surgical. Four cases are presented and the syndrome reviewed.
甲状腺髓样癌是一种罕见且不常见的恶性肿瘤。自15年前被描述以来，已发现许多新特征。从肿瘤中已分离出许多与该疾病不同症状直接相关的生物活性化合物。存在家族性发病情况，并且与其他肿瘤及其行为的关联增加。其起源细胞是滤泡旁细胞，该细胞分泌降钙素并导致甲状腺髓样癌的异常行为。治疗主要是手术治疗。本文报告4例病例并对该综合征进行综述。
