Sanders W E, Sorrentino R A, Greenfield R A, Shenasa H, Hamer M E, Wharton J M
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
J Am Coll Cardiol. 1994 Mar 15;23(4):926-34. doi: 10.1016/0735-1097(94)90639-4.
This study evaluates 1) the safety and efficacy of catheter delivery of radiofrequency current to eliminate sustained sinoatrial node reentrant tachycardia; 2) the incidence of sinoatrial node reentrant tachycardia in the current group of patients undergoing electrophysiologic study for paroxysmal supraventricular tachycardia; and 3) the association of sinoatrial node reentrant tachycardia with other tachyarrhythmias.
Sustained sinoatrial node reentrant tachycardia is an uncommon cause of paroxysmal supraventricular tachycardia that is reported to occur infrequently in conjunction with other arrhythmias. Although pharmacologic and surgical therapies are available, there is limited information with regard to catheter ablation of sinoatrial node reentrant tachycardia.
Ten patients with sustained sinoatrial node reentrant tachycardia underwent electrophysiologic study and radiofrequency current ablation. Patients were followed up for 9.2 +/- 6.0 months.
Of 343 consecutive patients referred for electrophysiologic evaluation of paroxysmal supraventricular tachycardia, 11 (3.2%) were found to have inducible sustained sinoatrial node reentrant tachycardia. Nine of the 11 patients had other associated arrhythmias, including atrioventricular (AV) node reentrant tachycardia (6 patients), AV reciprocating tachycardia (2 patients), ectopic atrial tachycardia (2 patients) and bundle branch reentrant tachycardia (1 patient). In 10 patients, direct ablation of sinoatrial node reentrant tachycardia was attempted and was successful in all (confidence interval for failure 0-0.26). Sinoatrial node reentrant tachycardia was eliminated with a median of four radiofrequency current applications (range 1 to 10) at 20 to 30 W. Successful ablation site characteristics during sinoatrial node reentrant tachycardia included 1) atrial activation > or = 35 ms (mean 44 +/- 8 ms) before the onset of the surface P wave, 2) atrial activation > or = 20 ms (mean 28 +/- 6 ms) before the onset of high right atrial activation, and 3) significantly prolonged and fractionated electrograms (mean duration 87 +/- 21 ms). No complications were encountered, and there have been no recurrences of sinoatrial node reentrant tachycardia.
Sinoatrial node reentrant tachycardia may be effectively and safely treated with radiofrequency current ablation at the site of earliest atrial activation.
本研究评估1)经导管输送射频电流消除持续性窦房结折返性心动过速的安全性和有效性;2)在当前接受阵发性室上性心动过速电生理研究的患者组中,窦房结折返性心动过速的发生率;3)窦房结折返性心动过速与其他快速性心律失常的关联。
持续性窦房结折返性心动过速是阵发性室上性心动过速的一种罕见病因,据报道很少与其他心律失常同时发生。虽然有药物和手术治疗方法,但关于窦房结折返性心动过速导管消融的信息有限。
10例持续性窦房结折返性心动过速患者接受了电生理研究和射频电流消融。对患者进行了9.2±6.0个月的随访。
在343例连续接受阵发性室上性心动过速电生理评估的患者中,11例(3.2%)被发现可诱发持续性窦房结折返性心动过速。11例患者中有9例有其他相关心律失常,包括房室结折返性心动过速(6例)、房室折返性心动过速(2例)、房性异位性心动过速(2例)和束支折返性心动过速(1例)。对10例患者尝试直接消融窦房结折返性心动过速,全部成功(失败的置信区间为0 - 0.26)。在20至30瓦功率下,平均4次(范围1至10次)射频电流应用消除了窦房结折返性心动过速。窦房结折返性心动过速消融成功部位的特征包括:1)体表P波起始前心房激动≥35毫秒(平均44±8毫秒);2)高位右房激动起始前心房激动≥20毫秒(平均28±6毫秒);3)显著延长和碎裂的电图(平均持续时间87±21毫秒)。未发生并发症,且窦房结折返性心动过速无复发。
在最早心房激动部位进行射频电流消融可有效、安全地治疗窦房结折返性心动过速。