Jackson L A, Tenover F C, Baker C, Plikaytis B D, Reeves M W, Stocker S A, Weaver R E, Wenger J D
Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333.
J Infect Dis. 1994 Feb;169(2):438-41. doi: 10.1093/infdis/169.2.438.
To estimate the prevalence of Neisseria meningitidis relatively resistant to penicillin in the United States, antimicrobial susceptibility testing was performed on all US meningococcal isolates submitted to the Centers for Disease Control and Prevention in 1991, including isolates identified through population-based surveillance for invasive meningococcal disease in selected areas of the United States. Three of the 100 isolates tested had MICs of penicillin of 0.125 microgram/mL. All were serogroup B, beta-lactamase-negative, and unique by multilocus enzyme electrophoresis subtyping. None of the 3 patients had been treated solely with penicillin; all recovered completely. About 4% of the isolates obtained from the population-based surveillance system were relatively penicillin-resistant. Given the low prevalence and uncertain clinical significance of infection with these organisms, routine susceptibility testing of meningococcal isolates is not indicated at this time; however, continued surveillance is necessary to monitor trends in antimicrobial susceptibility of meningococci in the United States.
为估算美国对青霉素相对耐药的脑膜炎奈瑟菌的流行情况，对1991年提交给疾病控制与预防中心的所有美国脑膜炎球菌分离株进行了药敏试验，包括通过美国特定地区侵袭性脑膜炎球菌病的人群监测确定的分离株。在检测的100株分离株中，有3株青霉素的最低抑菌浓度（MIC）为0.125微克/毫升。所有菌株均为B群，β-内酰胺酶阴性，且通过多位点酶电泳亚型分析具有独特性。这3例患者均未仅接受青霉素治疗；全部完全康复。从人群监测系统获得的分离株中约4%对青霉素相对耐药。鉴于这些微生物感染的低流行率和不确定的临床意义，目前不建议对脑膜炎球菌分离株进行常规药敏试验；然而，持续监测对于监测美国脑膜炎球菌药敏趋势是必要的。
