[光刺激引起的脑血流反应的刺激时间依赖性]

[Stimulus time dependence of cerebral blood flow response to photic stimulation].

作者信息

Kuwabara Y, Ichiya Y, Otsuka M, Sasaki M, Akashi Y, Yoshida T, Fukumura T, Masuda K, Ichimiya A

机构信息

Department of Radiology, Faculty of Medicine, Kyushu University, Fukuoka.

出版信息

Kaku Igaku. 1993 Dec;30(12):1491-5.

PMID:8107320

Abstract

The time dependency of rCBF response to photic stimulation in the primary visual cortices was studied using H215O bolus-injection and PET. The subjects consisted of 5 normal volunteers aged from 25 to 40 years old. Their regional CBF was measured at 2 min and 7 min after the start of photic stimulation (frequency, 10 Hz). The percentage increases of rCBF were 19.6 +/- 7.9% (mean +/- SD, range: 8.9-27.6%) in the primary visual cortex on the left side and 23.2 +/- 13.6% (2.5-35.8%) on the right side at 2 min, respectively, while, in comparison, they were 25.3 +/- 20.0% (1.8-49.7%) on the left side and 25.3 +/- 16.4% (3.5-44.5%) on the right side at 7 min, respectively. No significant difference was found in the rCBF responses between at 2 min and 7 min. Therefore, the taming effect does not need to be considered when carrying out a photic stimulation study.

摘要

使用H215O团注法和正电子发射断层扫描（PET）研究了初级视觉皮层中rCBF对光刺激反应的时间依赖性。受试者为5名年龄在25至40岁之间的正常志愿者。在光刺激（频率为10Hz）开始后2分钟和7分钟测量他们的局部脑血流量（rCBF）。在2分钟时，左侧初级视觉皮层的rCBF增加百分比为19.6±7.9%（平均值±标准差，范围：8.9 - 27.6%），右侧为23.2±13.6%（2.5 - 35.8%）；相比之下，在7分钟时，左侧为25.3±20.0%（1.8 - 49.7%），右侧为25.3±16.4%（3.5 - 44.5%）。在2分钟和7分钟时的rCBF反应之间未发现显著差异。因此，在进行光刺激研究时无需考虑驯化效应。