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[1例因腕部结核使用肾上腺皮质类固醇药物后发生粟粒性结核的病例]

[A case of miliary tuberculosis after adrenocorticosteroid medication for tuberculosis of the wrist].

作者信息

Miyazawa H, Suzuki K, Yamagishi F, Sasaki Y, Sugito K, Ihara S

机构信息

Division of Thoracic Disease, National Chiba, Higashi Hospital, Japan.

出版信息

Kekkaku. 1994 Jan;69(1):15-9.

PMID:8107348
Abstract

This report is a case study of miliary tuberculosis that was induced when adrenocorticosteroid treatment for tuberculosis of the wrist was given because of a mistaken diagnosis of rheumatoid arthritis. An 85-year-old man was admitted to a hospital with a fever and chest pains. Since an examination of the chest X-ray revealed fine nodules throughout both lungs and a sputum smear tested positive for acid-fast bacilli, he was transferred to our hospital. The patient had a three-year history of pain in his left wrist joint. He had swelling on the dorsal aspect of his left wrist for 1 1/2 years, and had been diagnosed as having rheumatoid arthritis. Prednisolone had been administered in dosages of 5 mg per day for two months and 5 mg every other day for four months prior to admission. Upon admission to the hospital, an X-ray examination of the wrist revealed marked destruction of the left carpal bones. Smears of fluid aspirated from the swelling showed acid-fast bacilli, and cultures grew M. tuberculosis. He was treated with INH, RFP and SM, however, he had complications of tuberculous spondylitis and renal tuberculosis, and died nine months after admission.

摘要

本报告是一例粟粒性肺结核的病例研究,该病例是因误诊为类风湿关节炎而对腕部结核进行肾上腺皮质类固醇治疗后引发的。一名85岁男性因发热和胸痛入院。由于胸部X线检查显示双肺布满小结节,痰涂片抗酸杆菌检测呈阳性,他被转至我院。患者有三年的左手腕关节疼痛病史。左手腕背侧肿胀1年半,曾被诊断为类风湿关节炎。入院前,泼尼松龙已按每日5毫克的剂量服用两个月,入院前四个月每隔一天服用5毫克。入院时,腕部X线检查显示左腕骨明显破坏。从肿胀处抽取的液体涂片显示抗酸杆菌,培养物培养出结核分枝杆菌。他接受了异烟肼、利福平及链霉素治疗,然而,他出现了结核性脊柱炎和肾结核并发症,并在入院九个月后死亡。

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